The grips are not unusual. Here're similarly shaped:
http://www.oriental-arms.com/photos.php?id=274
Agree with Ariel and Ward - Central Asian, perhaps Buharan or other ...stan countries. I have very similar dagger with large horn grips, and the hold is quite comfortable even for my small hands:-).
The blade is very nice indeed, Steve. The ladder pattern is rare on daggers, and yours is of good quality. My guess would be that the blade is older than the rest, and the chiseling is fairly recent, and not contemporary with the blade. Here is example of 18th century Persian chiseling, note the difference in quality.